Applications and perspectives of delivery vector-based nanovaccines in infectious disease and cancer control
The infection risk of traditional inactivated and attenuated vaccines and the low immunogenicity of subunit vaccines have limited the clinical application of vaccines.In recent years,vaccines based on nano-delivery carriers have attracted widespread attention for their excellent targeted delivery and antigen presentation.By regulating the physicochemical properties of nano-delivery carriers,nano-delivery carrier-based vaccines can mimic the natural infection process,accurately and rapidly deliver specific antigens to lymph nodes or target sites,promote cross-presentation of antigens,activate effector immune cells,and induce strong immune responses.Nanovaccines can also be combined with drugs such as immune checkpoint inhibitors and tumor angiogenesis inhibitors to prevent disease recurrence and reduce their adverse effects.This paper reviews the passive targeting,biocompatibility,active targeting,immune response improvement and mucosal immune response induction functions of nano-delivery vectors,as well as the progress of the application of nano-delivery vector-based vaccines in the immunotherapy of tumors,autoimmune diseases and prevention of infectious diseases in recent years,and discusses their future development and challenges.
NETL
NSTL
万方数据
