Study of continuous hemodialysis combined with Shenshuaining Granule on inflammatory response,residual renal function and CTGF expression in patients with renal failure
Objective To explore the study of continuous hemodialysis combined with Shenshuaining Granule on inflammatory response,residual renal function and connective tissue growth factor(CTGF)expression in renal failure patients.Methods From July 2022 to July 2023,200 patients with renal failure who attended the Huangpu branch of the Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine were selected and randomly divided into control group and experimental group,100 cases in each group,and both groups were treated with continuous hemodialysis,and the experimental group was given Shenshuaining Granule on the basis of which,one sachet per time,three times per day,treatment for three months.Observe the inflammatory reaction,residual renal function and CTGF expression in both groups.Results Compared with the control group,the total effective rate of the experimental group(94.00％)was significantly higher than that of the control group(71.00％),and the difference between the groups was obvious(P＜0.05).There was no significant difference in the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and nuclear factor κB inhibitory protein-α(IκB-α)between the two groups before treatment;after treatment,the levels of IL-6,TNF-α,and IκB-α in the two groups were significantly reduced(P＜0.05),and the experimental group was reduced significantly compared with the control group(P＜0.05).There was no significant difference in the comparison of blood creatinine(SCr),blood cystatin-C(CCys-C),and glomerular filtration rate(GFR)levels between the two groups before treatment;after treatment,the levels of SCr,CCys-C,and GFR in the two groups were significantly reduced(P＜0.05),and the experimental group was significantly lower than the control group(P＜0.05).There was no significant difference in the comparison of CTGF expression between the two groups before treatment;after treatment,CTGF expression was significantly reduced in both groups(P＜0.05),and the test group was significantly lower than the control group(P＜0.05).The total adverse reaction rate of the experimental group(5.00％)was significantly lower than that of the control group(13.00％),and the difference between the groups was statistically significant(P＜0.05).Conclusion Continuous hemodialysis combined with Shenshuaining Granule has significant efficacy in patients with renal failure,which can significantly improve the inflammatory response,improve residual renal function,and significantly inhibit CTGF expression.
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