Research progress of traditional Chinese medicine regulating CX43 to alleviate myocardial ischemia injury
Myocardial ischemia is a common clinical disease.Traditional Chinese medicine has a clear effect on the prevention and treatment of myocardial ischemia injury,and its mechanism is a hot research topic.Connexion 43(Cx43)is a major component of gap junctions that mediate electrical coupling between adjacent cardiomyocytes.During myocardial ischemia,the abnormal distribution,expression and phosphorylation of Cx43 in cardiomyocytes may contribute to the development of myocardial ischemia by affecting gap junction function.This paper summarized the research progress of traditional Chinese medicine monomers and their active components(including sanguis draconis flavones,flavonoids in angelica sinensis,flavonoids in hypericum attenuatum choisy,ginkgetin,panax notoginseng saponins,hyperoside,salidroside,astragaloside Ⅳ,sophocarpine,ligustrazine,dauricine,resveratrol,danshensu),as well as traditional Chinese medicine compounds and preparations(including Yiqi Huoxue Prescription,Wenxin Granules,Compound Huangqi Yangxin Mixture,Fumai Decoction,Wutou Chishishhi Pill Formula,Yangxin Dingji Capsule,Zhishi Xiebai Guizhi Decoction,Zhuangtong Yin,Chaihu Sanshen Capsule,Shensong Yangxin Capsule),in improving gap junction function and alleviating myocardial ischemia injury by regulating Cx43,in order to provide theoretical guidance for the development of new traditional Chinese medicine products and clinical use of myocardial ischemia.
traditional Chinese medicine monomertraditional Chinese medicine compoundmyocardial ischemiaconnexin 43Panax notoginseng saponinssalidrosideastragaloside ⅣWenxin GranulesShensong Yangxin Capsule
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