Based on network pharmacology to explore mechanism of Armeniacae Semen Amarum-Scutellariae Radix on treatment of corona virus disease 2019
Objective To explore corona virus disease 2019(COVID-19)targets and signal pathways through the pharmacology of almond and scutellaria,and to explain the mechanism.Methods TCMSP and BATMAN databases were used to screen the active components and targets of Armeniacae Semen Amarum-Scutellariae Radix.Genecards database was used to screen the predicted targets of COVID-19.The two targets were mapped to screen out the same targets of almond Scutellaria and COVID-19.String was used to build PPI network for these common targets,and metascape was used for go biological process enrichment and KEGG pathway analysis.And the network map of active components and targets was constructed with the database of Cytoscape 3.7.2 and the core targets were screened out.Results According to the screening conditions,32 active components,137 potential targets,820 biological processes involved in the regulation of inflammatory response,82 pathways of tuberculosis and pertussis were obtained.Conclusion Armeniacae Semen Amarum-Scutellariae Radix can inhibit cytokine storm,cough and other pharmacological effects through multiple targets and channels,and finally achieve the therapeutic effect of COVID-19.
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