Analysis of medication rules and mechanism of traditional Chinese medicine compound patent in treating gastric cancer based on data mining and network pharmacology
Objective To analyze the medication rule and mechanism of traditional Chinese medicine compound of national patent database in treating gastric cancer based on data mining and network pharmacology.Methods The patent of TCM compound for treating gastric cancer from inception to October 2023 were searched by national patent database.The prescription database was established with Microsoft Excel software.The ancient and modem medical case cloud platform and IBM SPSS Modeler were used to perform attribute analysis,frequency analysis,association rule analysis,and cluster analysis.TCMSP was used to obtain the effective constituents and target sites of Hedyoti Diffusae Herba,Scutellariae Barbatae Herba and Astragali Radix.Disease targets of gastric cancer were obtained by GeneCards,DrugBank,OMIM,PharmGkb and TTD databases.R language was used to screen common targets.Target protein interaction PPI network was constructed using STRING database.Construct drug component-disease target network map and screen common target core targets using Cytoscape software.KEGG analysis using R language.Results A total of 287 TCM compound patents were included,including 838 Chinese herbs.They came from 24 provinces,municipalities and autonomous regions.Their properties were mainly warm,average and cold,the tastes were mainly sweet,bitter and pungent.Drugs were mainly belong to spleen,liver and lung channel tropism.High-frequency single traditional Chinese medicines include hedyotis diffusae,Astragalus membranaceus,licorice,atractylodes macrocephala and Scutellaria barbata,etc.High-frequency drug pairs including"Hedyoti Diffusae Herba-Astragali Radix"and"Hedyoti Diffusae Herba-Scutellariae Barbatae Herba".The association rule analysis obtained 15 drug groups.Three core drug groups were obtained by cluster analysis of high-frequency drugs.There were 44 effective components and 272 targets of high frequency drug against Hedyoti Diffusae Herba,Scutellariae Barbatae Herba aond Astragali Radix.There were 8 961 targets in gastric cancer,and 198 common targets were identified by screening.KEGG pathway enrichment analysis showed 83 related pathways,mainly concentrated in cancer signaling pathway,apoptosis signaling pathway,P53 signaling pathway,etc.Conclusion The treatment of gastric cancer with traditional Chinese medicine compound has an obvious rule.In the treatment of gastric cancer,the formula can be combined with cold and warm drugs,and the basic treatment is to enhance body function and inhibit tumor growth.The mechanism is characterized by multiple components,targets and pathways.
gastric cancertraditional Chinese medicine compoundnational patentdata miningnetwork pharmacology compatibility lawHedyoti Diffusae HerbaScutellariae Barbatae HerbaAstragali Radix
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