Applications and advances in use of Xenopus laevis in drug screening and evaluation
As a classical model organism,Xenopus laevis plays an important role in the establishment of disease models,drug screening,and pharmacological mechanism research,mainly due to its unique biological characteristics.The advantages of the application of X.laevis in drug research are mainly in genetic similarity,anatomical and physiological similarity,embryonic transparency and easy observation,and the feasibility of gene editing.Commonly used drug screening methods in X.laevis include phenotype-based drug screening,cell-free screening system and oocyte screening system.Currently,X.laevis has made some progress in the screening of therapeutic drugs for neurological diseases,anti-tumor drugs,metabolic diseases,and rare diseases,as well as in the evaluation of drug safety,drug metabolism,and pharmacodynamic evaluation.We summarize the advantages of X.laevis as a model organism and its applications in drug research,and also discuss the challenges in its development and application prospects,with a view to selecting more efficient model organisms for drug screening and evaluation.
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