Research progress of traditional Chinese medicine on prevention and treatment of metabolism-associated fatty liver disease based on Nrf2 signaling pathway
Metabolism-associated fatty liver disease(MAFLD,formerly known as nonalcoholic fatty liver disease)is a typical obesity-induced liver disease and is considered to be the most common liver disease.MAFLD is a complex disease associated with a variety of genetic,epigenetic,and environmental associations,and the mechanisms of its pathogenesis are still not fully understood.Recent studies have shown that elevated levels of oxidative stress are one of the major causes of MAFLD formation.The nuclear factor E2-related factor 2(Nrf2)signaling pathway is an important anti-oxidative stress pathway,and the Nrf2 pathway reduces the production of reactive oxygen species(ROS)and increases the expression of antioxidant enzymes and proteins,whereas traditional Chinese medicines can reduce the oxidative stress of hepatocytes by activating the Nrf2-mediated antioxidant response,thus playing a role in the prevention and treatment of metabolism-related fatty liver disease.We summarize the single herbs and compound formulas that can reduce the overproduction of ROS,generate antioxidant responses and reduce inflammatory responses through regulating the Nrf2 pathway,and play a therapeutic role in the treatment of MAFLD,so as to provide a reference for the discovery of highly effective herbs for the prevention and treatment of MAFLD.
metabolism-associated fatty liver diseasenon-alcoholic fatty liver diseaseoxidative stressnuclear factor E2-related factor 2(Nrf2)reactive oxygen speciestraditional Chinese medicine
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