药物评价研究2024,Vol.47Issue(11) :2688-2696.DOI:10.7501/j.issn.1674-6376.2024.11.025

黄芩苷药理活性和作用机制研究进展

Research progress of pharmacological effects and mechanism of baicalin

侯晓杰 张建锋 侯长周 周礼杰 代华 张石宇 李玮
药物评价研究2024,Vol.47Issue(11) :2688-2696.DOI:10.7501/j.issn.1674-6376.2024.11.025

黄芩苷药理活性和作用机制研究进展

Research progress of pharmacological effects and mechanism of baicalin

侯晓杰 1张建锋 2侯长周 3周礼杰 3代华 4张石宇 5李玮1
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作者信息

  • 1. 贵州中医药大学药学院,贵州贵阳 550025;贵州中药炮制技术传承基地,贵州贵阳 550025
  • 2. 贵州威利德制药有限公司,贵州贵阳 550014
  • 3. 贵州中医药大学药学院,贵州贵阳 550025
  • 4. 贵州大学药学院,贵州贵阳 550025
  • 5. 贵州中医药大学第一附属医院,贵州贵阳 550001
  • 折叠

摘要

黄芩苷是从唇形科双子叶植物黄芩Scutellaria baicalensis的干燥根中提取分离出来的一种黄酮类化合物,对黄芩苷的药理作用及机制研究的关注度越来越高,主要具有抗病毒、抗肿瘤、抗炎、抗菌、神经保护、抗氧化等药理活性,还具有抗抑郁、调节免疫、安胎、降压、镇痛等药理作用.为更充分开发黄芩苷的药用价值,对黄芩苷的主要药理活性和相关作用机制进行分类整理,旨在为黄芩苷的临床应用及新药研发提供科学依据.

Abstract

Baicalin is a flavonoid compound extracted and isolated from the dried roots of Scutellaria baicalensis,a dicotyledonous plant in the family Lamiaceae.The pharmacological effects and mechanisms of baicalin have received increasing attention,mainly exhibiting antiviral,anti-tumor,anti-inflammatory,antibacterial,neuroprotective,antioxidant and other pharmacological activities.It also has pharmacological effects such as antidepressant,immune regulation,miscarriage control,blood pressure reduction,and analgesia.In order to fully develop the medicinal value of baicalin,the main pharmacological activities and related mechanisms of action of baicalin are classified and organized,aiming to provide scientific basis for the clinical application and new drug development of baicalin.

关键词

黄芩苷/抗病毒/抗炎/抗菌/抗肿瘤/神经保护/抗氧化

Key words

baicalin/antiviral/anti-inflammatory/antibacterial/anti-tumor/neuroprotection/antioxidant

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出版年

2024
药物评价研究
天津药物研究院 中国药学会

药物评价研究

CSTPCD北大核心
影响因子:1.199
ISSN:1674-6376
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