Clinical comprehensive evaluation of Simo Decoction in treatment of functional dyspepsia(syndrome of qi stagnation and food accumulation)in adults
Objective To evaluate the multi-dimensional value of Simo Decoction Oral Liquid in the treatment of adult functional dyspepsia(qi stagnation and food retention syndrome)through a systematic method,promote the return of proprietary Chinese medicines to clinical value,and improve the scientific use level of proprietary Chinese medicines.Methods According to the Guidelines for the Comprehensive Evaluation of Proprietary Chinese Medicines(Trial Version 2022),using evidence-based analysis,pharmacoeconomics,questionnaire surveys,etc.,a comprehensive evaluation of the safety,efficacy,cost-effectiveness,innovation,suitability,accessibility,and traditional Chinese medicine characteristics(6+1 dimensions)of Simo Decoction Oral Liquid in the treatment of adult functional dyspepsia(qi stagnation and food retention syndrome)was conducted,and a multi-criteria decision analysis model(MCDA)was used for comprehensive scoring.Results In terms of safety,based on comprehensive literature reports of adverse reactions,data from the National Adverse Reaction Monitoring Center,toxicological studies,etc.,it is concluded that Simo Decoction Oral Liquid has relatively mild adverse reactions.In terms of efficacy,Meta-analysis results show that compared with conventional treatment,the total effective rate of Simo Decoction Oral Liquid and Simo Decoction Oral Liquid+conventional treatment is better(P＜0.05).In terms of cost-effectiveness,compared with domperidone,Simo Decoction Oral Liquid is more cost-effective in improving symptoms such as belching and hiccupping.In terms of innovation,there are innovations in the enterprise service system and industry.In terms of suitability,questionnaire survey results suggest that Simo Decoction Oral Liquid has high suitability for both medical staff and patients.In terms of accessibility,the product has a wide coverage,is reimbursable by medical insurance,and has good sustainability.In terms of traditional Chinese medicine characteristics evaluation,the prescription of Simo Decoction Oral Liquid comes from"Dou Zhen Jin Jing Lu",the prescription conforms to traditional Chinese medicine theory,originates from classic prescriptions of the Ming Dynasty,and has obvious traditional Chinese medicine characteristics.Conclusion The evaluation results of each dimension of Simo Decoction Oral Liquid and the comprehensive score of MCDA all indicate that Simo Decoction Oral Liquid has good clinical value in the treatment of adult functional dyspepsia(qi stagnation and food retention syndrome).
Simo Decoction Oral Liquidfunctional dyspepsiasyndrome of qi stagnation and food accumulationclinical comprehensive evaluationChinese patent medicine
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