Meta-analysis of safety and efficacy of Shenyi Capsule combined with chemotherapy in treatment of cancer
Objectives To evaluate the effects of Shenyi Capsule combined with chemotherapy on clinical efficacy,safety and immune function of cancer patients.Methods All randomized controlled trials(RCT)of Shenyi Capsule combined with chemotherapy in the treatment of malignant tumors were searched from CNKI,WanFang Data,VIP,CBM,PubMed,Web of Science,The Cochrane Library,Embase databases.The search period was limited from the databases establishment to June 25,2024.Revman 5.3 software was used for Meta-analysis,and forest maps were drawn,followed by sensitivity analysis and funnel plot bias evaluation.Results A total of 24 RCT were included.Compared with chemotherapy alone,in terms of efficacy,Shenyi Capsule combined chemotherapy group could significantly improve objective response rate(ORR)[OR=2.28(1.85,2.81),P＜0.000 01]and disease control rate(DCR)[OR=2.47(1.88,3.25),P＜0.000 01],decrease VEGF levels[MD=-71.02(-77.99,-64.05),P＜0.000 01],and improve quality of life[OR=2.75(2.10,3.61),P＜0.000 01].In terms of safety,Shenyi Capsule combined with chemotherapy showed no significant difference in the occurrence of Ⅲ,Ⅳ grade of gastrointestinal adverse reactions[OR=0.69(0.37,1.30),P=0.25],but significantly improved the Ⅲ,Ⅳ grade of leukopenia[OR=0.28(0.18,0.43),P＜0.000 01]and thrombocytopenia[OR=0.48(0.26,0.88),P=0.02].In terms of immune function,the level of CD3+T cells[MD=6.47(4.56,8.37),P＜0.000 01],the level of CD4+T cells[MD=5.87(5.28,6.46),P＜0.000 01]and CD4+/CD8+T cell levels[MD=0.41(0.24,0.57),P＜0.000 01]in the combination group.But there was no significant difference in improving CD8+T cell levels[MD=2.25(-0.47,4.97),P=0.10].Conclusion Shenyi Capsule combined with chemotherapy can significantly improve the clinical efficacy,reduce the incidence of adverse reactions,and improve the immune function to a certain extent,so as to achieve the therapeutic effect of enhancing efficiency and reducing toxicity.
Shenyi CapsuleMeta-analysischemotherapyadverse drug reactionimmune functionmalignant tumors
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