Research advancement of natural products of traditional Chinese medicine in regulating Nrf2 signaling pathway for prevention and treatment of Alzheimer's disease
Alzheimer's disease(AD)is a complex and age-related progressive neurodegenerative disorder,the most common form of dementia,characterized by the progressive deterioration of cognitive function,language,and behavioral deficits.Abnormal deposition of beta amyloid protein(Aβ),neurofibrillary tangles(NFT),low levels of acetylcholine,Calcium ion steady-state imbalance,oxidative stress,and neuroinflammation are believed to play key roles in the pathogenesis of AD.Nrf2 is a significant transcriptional regulator that plays multiple roles in redox homeostasis,protein degradation,DNA repair,regulation of exogenous metabolism,and immune response.Nrf2 has emerged as a major target in the fields of inflammation and tumor therapy and has received extensive attention in the prevention and treatment of AD.The natural products of Chinese medicine play an irreplaceable role in the prevention and treatment of AD.Based on this,summarize and generalize the relationship between Nrf2 and AD,as well as the mechanism of regulating the Nrf2 signaling pathway by natural Chinese medicine products to prevent and treat AD,in order to provide reference for the treatment of AD and the development of new drugs.
Alzheimer's diseasenatural productsnuclear factor E2 related factor 2oxidative stressinflammation
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