Ibuprofen,one of the most commonly used nonsteroidal anti-inflammatory drugs in clinic,has anti-inflammatory,analgesic and other pharmacological activities.In recent years,its anti-tumor activity has received extensive attention.However,due to the lack of selectivity and water solubility of ibuprofen,as well as the presence of free carboxyl groups in its structure that can cause adverse reactions in the gastrointestinal tract,its further application in anti-tumor therapy is limited.In addition,the anti-tumor mechanism of ibuprofen is not completely elucidated.Therefore,in order to improve the bioavailability and adverse effects of ibuprofen and to find new targets,researchers have designed and synthesized new ibuprofen derivatives by various methods.In this paper,the research progress of ibuprofen amide derivatives,ester derivatives,metal complexes and other derivatives with antitumor activity is reviewed to provide reference for the subsequent research,development and utilization of ibuprofen structural modifiers as anti-tumor drugs.
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