Research progress on drugs playing anti-tumor effects by regulating superoxide dismutase
Superoxide dismutase(SOD)is one of the major biological enzymes widely present in living organisms,which can effectively scavenge reactive oxygen species(ROS)and plays a crucial role in maintaining the oxidative and antioxidant balance of the body.In recent years,with the in-depth study of SOD,it is found that the expression of its activity has a very close relationship with the occurrence,development and prevention of malignant tumors.Modern pharmacological studies have found that pharmacological modulation of SOD expression can affect the proliferation,metastasis and invasion of tumor cells,and also promote tumor death.SOD shows differential expression in different tumors,and SOD expression is elevated in prostate,lung,cervical,and nasopharyngeal cancers,and inhibition of SOD expression in these tumors by SOD inhibitors can promote apoptosis and inhibit tumor growth.While in gastric cancers,the inhibitor can promote apoptosis and inhibit tumor growth.In gastric cancers,the activity of SOD was found to be decreased,and the use of SOD mimics to induce apoptosis of gastric cancer cells.In colorectal and nasopharyngeal cancers,the high expression of SOD was found,and the use of drugs to down-regulate the expression of SOD was able to promote the apoptosis of colorectal and nasopharyngeal cancers,in which down-regulation of the expression of SOD in colorectal cancers was also able to inhibit the metastasis and invasion of cancer cells.Drugs can exert antitumor effects by regulating SOD expression,which is mainly related to the role of SOD in scavenging ROS.The antitumor pharmacological effects of drugs modulating SOD expression and the current status of clinical research were sorted out,with a view to providing reference for the development of novel antitumor drugs and adjuvant therapeutic means.
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