As the major biological activity components, Lycium barbarum polysaccharides have attracted tremendous attentions due to their antitumor and immunoregulation functions. Current research progress in the structure characterization and biological activities of polysaccharides from Lycium barbarum are reviewed in this paper.Meanwhile, problems encountered during the investigations ofLycium barbarum polysaccharidesare also discussed, which will provide a useful guidance for future studies.