目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取 2020 年 8 月—2022 年 8 月无锡市康复医院收治的 88 例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组，各 44 例。两组均给予常规治疗，对照组给予谷红注射液，研究组在对照组基础上给予中药热敷。比较两组治疗后临床效果、治疗前后神经功能、认知功能、血清学指标、脑血流动力学。结果:研究组总有效率为 95。45%，显著高于对照组的 79。55%，差异有统计学意义(P<0。05)。治疗后，研究组蒙特利尔认知评估量表(Montreal cognitive assessment，MoCA)、简易智能精神状态检查量表(mini-mental state examination，MMSE)评分均高于对照组，美国国立卫生研究院卒中量表(National Institute of Health stroke scale，NIHSS)评分明显低于对照组，差异有统计学意义(P<0。05)。治疗后，研究组S-100 钙结合蛋白β(S-100 calcium binding protein β，S-100β)、视锥蛋白样蛋白-l(visinin like protein 1，VILIP-1)水平均低于对照组，胰岛素样生长因子 1(insulin-like growth factor 1，IGF-1)水平高于对照组，差异有统计学意义(P<0。05)。治疗后，研究组收缩期峰值流速(peak flow velocity of systole，Vp)、平均血流速度(mean velocity，Vm)均高于对照组，搏动指数(pulse index，PI)低于对照组，差异有统计学意义(P<0。05)。结论:谷红注射液联合中药热敷治疗卒中后认知障碍患者能促进神经功能恢复，改善认知功能，改善脑血流动力学，提高治疗效果。
Clinical Effect of Safflower and Aceglutamide Injection Combined with Traditional Chinese Medicine Hot Compress in the Treatment of Post-stroke Cognitive Impairment
Objective:To explore the clinical effect of Safflower and Aceglutamide Injection combined with traditional Chinese medicine hot compress in the treatment of post-stroke cognitive impairment.Method:A total of 88 patients with post-stroke cognitive impairment admitted to Wuxi Rehabilitation Hospital from August 2020 to August 2022 were prospectively selected.They were divided into study group and control group,44 cases in each group.Both groups were given conventional treatment,the control group was given Safflower and Aceglutamide Injection,and the study group was given traditional Chinese medicine hot compress on the basis of the control group.The clinical effect after treatment,neurological function,cognitive function,serological index and cerebral hemodynamics before and after treatment were compared between the two groups.Result:The total effective rate of the study group was 95.45%,which was significantly higher than 79.55%of the control group,the difference was statistically significant(P<0.05).After treatment,the scores of Montreal cognitive assessment(MoCA)and mini-mental state examination(MMSE)in the study group were higher than those in the control group,the score of the National Institute of Health stroke scale(NIHSS)was significantly lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of S-100 calcium binding protein β(S-100β)and visinin like protein 1(VILIP-1)in the study group were lower than those in the control group,and the level of insulin-like growth factor 1(IGF-1)was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,the peak flow velocity of systole(Vp)and mean velocity(Vm)of the study group were higher than those of the control group,and the pulse index(PI)was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Safflower and Aceglutamide Injection and traditional Chinese medicine hot compress can promote neurological function recovery,improve cognitive function,improve cerebral hemodynamics,and enhance treatment effectiveness in patients with post-stroke cognitive impairment.
Safflower and Aceglutamide InjectionTraditional Chinese medicine hot compressStrokeCognitive disorder
万方数据
维普
