Application Value of Fetal NT Ultrasound Combined with Facial Contour Ultrasound Index Screening in the Diagnosis of Down Syndrome
Objective:To explore the application value of fetal nuchal translucency(NT)ultrasound combined with facial contour ultrasound index screening in the diagnosis of Down syndrome.Method:A retrospective study was conducted,selecting 101 pregnant women who underwent fetal Down syndrome screening and were diagnosed at Jiangsu Shengze Hospital from January 2019 to June 2023 as the observation group.Additionally,80 pregnant women with normal fetal screening results during the same period were selected as the control group.The study compared the two groups in terms of fetal ultrasound NT thickness,the frontal-maxillary facial(FMF)angle,the maxillary-nasal-mandibular(MNM)angle,and the prenasal thickness to nasal bone length ratio(PT/NBL),as well as the diagnostic outcomes of each indicator.Receiver operating characteristic(ROC)curves were constructed to analyze the diagnostic efficiency of NT thickness alone,combined with the FMF angle,and combined with both the FMF angle and PT/NBL.Result:There was no significant difference in MNM angle between the two groups(P>0.05).The NT thickness,FMF angle and PT/NBL in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The detection rates of increased NT thickness,FMF angle and PT/NBL in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The detection rate of decreased MNM angle did not show a statistically significant difference compared to the control group(P>0.05).The combined diagnostic approach of NT thickness,FMF angle,and PT/NBL for Down syndrome had an area under the curve(AUC)of 0.940,which was significantly higher than the diagnosis using NT thickness(0.878)and the combined diagnosis of NT thickness and FMF angle(0.887).Conclusion:Increased NT thickness,enlarged FMF angle,and increased PT/NBL are associated with fetal Down syndrome.Compared to using NT thickness alone and the combination of NT thickness with FMF angle,the combined use of NT thickness,FMF angle and PT/NBL as parameters for fetal Down syndrome screening has a higher diagnostic value.
万方数据
维普
