Study on Expression and Correlation of Sex Hormones and Disease-related Factors in Patients with Polycystic Ovary Syndrome
Objective:To investigate the expression and correlation of sex hormones with plasma peroxidase reductase 6(PRDX6),serum anti-Müllerian hormone(AMH),heat shock protein 70(HSP70),uric acid(SUA)and ischemic modified albumin(IMA)in patients with polycystic ovary syndrome,and to provide reference for clinical treatment.Method:This study was a retrospective study,92 patients with polycystic ovary syndrome who diagnosed and treated in Yinan County Maternal and Child Health Hospital from February 2021 to December 2022 were selected as the observation group,and 95 women who underwent normal examination in our hospital during the same period were selected as the control group.The changes of sex hormones,plasma PRDX6 and serum AMH,HSP70,SUA,IMA levels and their correlation were compared between two groups.Result:The levels of serum follicle stimulating hormone(FSH)and estradiol(E2)in the observation group were lower than those in the control group,while the levels of serum luteinizing hormone(LH),testosterone(T),plasma PRDX6 and serum AMH,HSP70,SUA and IMA were higher than those in the control group,and the differences were statistically significant(P<0.05);however,there was no significant difference in serum PRL level between two groups(P>0.05).Serum FSH and E2 were negatively correlated with plasma PRDX6 and serum AMH,HSP70,SUA and IMA,serum LH were positively correlated with plasma PRDX6 and serum AMH,HSP70 and IMA,serum T were positively correlated with plasma PRDX6 and serum HSP70 and IMA,serum PRL were positively correlated with plasma PRDX6 and serum AMH,HSP70,SUA and IMA(P<0.05).Conclusion:The levels of sex hormones in patients with polycystic ovary syndrome are abnormal,and the levels of plasma PRDX6 and serum AMH,HSP70,SUA and IMA are increased,at the same time,there is certain correlation between sex hormone levels and plasma PRDX6 and serum AMH,HSP70,SUA and IMA levels,relevant indicators can be monitored to provide reference for clinical treatment of polycystic ovary syndrome.
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