摘要
目的:探讨多囊卵巢综合征患者性激素与血浆过氧化还原酶 6(PRDX6)、血清抗米勒管激素(AMH)、热休克蛋白 70(HSP70)、尿酸(SUA)、缺血修饰白蛋白(IMA)表达情况及其相关性,为临床治疗提供参考依据.方法:本次研究为回顾性研究,选择 2021 年 2 月—2022 年 12 月于沂南县妇幼保健院诊治的 92 例多囊卵巢综合征患者作为观察组,另选取同期在本院正常检查的 95 例女性为对照组.比较两组性激素、血浆PRDX6 及血清AMH、HSP70、SUA、IMA水平变化及其相关性.结果:观察组血清卵泡刺激素(FSH)、雌二醇(E2)低于对照组,血清黄体生成素(LH)、睾酮(T)、血浆PRDX6 及血清AMH、HSP70、SUA、IMA水平高于对照组,差异有统计学意义(P<0.05);但两组血清PRL水平比较,差异无统计学意义(P>0.05).血清FSH、E2 和血浆PRDX6 及血清AMH、HSP70、SUA、IMA呈负相关,血清LH和血浆PRDX6、血清AMH、HSP70、IMA呈正相关,血清T和血浆PRDX6 及血清HSP70、IMA呈正相关,血清PRL与血浆PRDX6 及血清AMH、HSP70、SUA、IMA呈正相关(P<0.05).结论:多囊卵巢综合征患者性激素水平异常,血浆PRDX6及血清AMH、HSP70、SUA、IMA水平升高,同时性激素水平与血浆PRDX6 及血清AMH、HSP70、SUA、IMA水平存在一定的相关性,可对相关指标进行监测,为临床治疗多囊卵巢综合征提供参考依据.
Abstract
Objective:To investigate the expression and correlation of sex hormones with plasma peroxidase reductase 6(PRDX6),serum anti-Müllerian hormone(AMH),heat shock protein 70(HSP70),uric acid(SUA)and ischemic modified albumin(IMA)in patients with polycystic ovary syndrome,and to provide reference for clinical treatment.Method:This study was a retrospective study,92 patients with polycystic ovary syndrome who diagnosed and treated in Yinan County Maternal and Child Health Hospital from February 2021 to December 2022 were selected as the observation group,and 95 women who underwent normal examination in our hospital during the same period were selected as the control group.The changes of sex hormones,plasma PRDX6 and serum AMH,HSP70,SUA,IMA levels and their correlation were compared between two groups.Result:The levels of serum follicle stimulating hormone(FSH)and estradiol(E2)in the observation group were lower than those in the control group,while the levels of serum luteinizing hormone(LH),testosterone(T),plasma PRDX6 and serum AMH,HSP70,SUA and IMA were higher than those in the control group,and the differences were statistically significant(P<0.05);however,there was no significant difference in serum PRL level between two groups(P>0.05).Serum FSH and E2 were negatively correlated with plasma PRDX6 and serum AMH,HSP70,SUA and IMA,serum LH were positively correlated with plasma PRDX6 and serum AMH,HSP70 and IMA,serum T were positively correlated with plasma PRDX6 and serum HSP70 and IMA,serum PRL were positively correlated with plasma PRDX6 and serum AMH,HSP70,SUA and IMA(P<0.05).Conclusion:The levels of sex hormones in patients with polycystic ovary syndrome are abnormal,and the levels of plasma PRDX6 and serum AMH,HSP70,SUA and IMA are increased,at the same time,there is certain correlation between sex hormone levels and plasma PRDX6 and serum AMH,HSP70,SUA and IMA levels,relevant indicators can be monitored to provide reference for clinical treatment of polycystic ovary syndrome.
维普
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