Efficacy of Vitamin B12 Combined with Perampanel in the Treatment of Focal Epilepsy after Stroke
Objective:To evaluate the efficacy of Vitamin B12 combined with Perampanel in the treatment of focal epilepsy after stroke.Method:A total of 132 patients with focal epilepsy after stroke treated in the Department of Neurology of Xuyi County People's Hospital from February 2019 to October 2022 were selected.According to the method of random number table,they were divided into control group and experimental group,66 cases in each group.Both groups were actively treated for the primary disease,the control group was given Perampanel Tablets,and the experimental group was given Vitamin B12 Tablets on the basis of the control group.The clinical efficacy after treatment,ambulatory eleroencephalography(AEEG)index,glucose and lipid metabolism,neural function,cognitive function,social function before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,the total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,the number of β wave and α wave in both group were decreased,and the number of β wave and α wave in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).Before and after treatment,there were no significant differences in fasting blood glucose(FBG)and total cholesterol(TC)between the two groups(P>0.05).After treatment,the scores of the Wisconsin card classification test(WCST)in the both group increased,and the scores of the National Institute of Health stroke scale(NIHSS)and the social dysfunction screening scale(SDSS)in the both group decreased,the WCST score in the experimental group was higher than that in the control group,while the NIHSS and SDSS scores were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in experimental groups was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion:Vitamin B12 combined with Perampanel has a significant effect in the treatment of focal epilepsy after stroke,which can effectively improve the neurological and cognitive functions of patients with few adverse reactions.
Ambulatory eleroencephalographyVitamin B12PerampanelFocal epilepsy after stroke
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