目的:探讨急性脑梗死(acute cerebral infarction，ACI)溶栓患者术后临床症状反复发作的相关影响因素。方法:采用回顾性调查方法对 2019 年 1 月—2023 年 2 月在张家港市第二人民医院神经内科诊治的 90 例ACI溶栓患者资料进行分析，以术后出现偏瘫、失语等临床症状反复发作的56例(62。22%)为观察组，未出现临床症状反复发作的34例(37。78%)为对照组，并对其进行单因素分析、logistic回归分析及受试者工作特征(receiver operating characteristic，ROC)曲线分析，研究ACI溶栓患者术后临床症状反复发作的相关因素。结果:单因素分析分析结果显示，两组性别、年龄、吸烟史、高血压史、糖尿病史、发病时间、血清生化指标比较，差异无统计学意义(P>0。05);两组美国国立卫生研究院卒中量表(National Institute of Health stroke scale，NIHSS)评分、心房颤动、梗死部位水平比较，差异有统计学意义(P<0。05)。logistic回归分析结果显示，NIHSS评分、心房颤动及梗死部位为ACI溶栓患者术后临床症状反复发作的独立危险因素(P<0。05)。ROC曲线分析结果显示，NIHSS评分、心房颤动及梗死部位的ROC曲线下面积(area under curve，AUC)分别为 0。899、0。637、0。654，敏感度较高。结论:ACI溶栓患者术后临床症状反复发作与脑卒中神经缺损程度、心房颤动及梗死部位有关。
Analysis of the Fluctuation of Postoperative Clinical Symptoms in Thrombolytic Patients with Acute Cerebral Infarction
Objective:To explore the influencing factors associated with fluctuating of postoperative clinical symptoms in thrombolysis patients with acute cerebral infarction(ACI).Method:A retrospective survey was used to analyze the data of 90 patients with ACI in Department of Neurology of Zhangjiagang Second People's Hospital from January 2019 to February 2023,and 56 cases(62.22%)of postoperative clinical symptoms such as hemiplegia and aphasia were set as the observation group,and 34 cases(37.78%)of no clinical symptoms were set as the control group,and the univariate analysis,logistic regression analysis and receiver operating characteristic(ROC)curve analysis were used to observe the factors associated with fluctuation of postoperative clinical symptoms in thrombolysis with ACI.Result:The results of univariate analysis showed that there were no differences in gender,age,smoking history,history of hypertension,diabetes,time of onset and serum biochemical indicators between the two groups(P>0.05).And there were statistically significant in National Institute of Health stroke scale(NIHSS)score,atrial fibrillation and infarction site between the two groups(P<0.05).The results of logistic regression analysis showed that NIHSS score,atrial fibrillation and infarction site were independent factors influencing the fluctuation of postoperative clinical symptoms in thrombolytic patients with ACI(P<0.05).The results of ROC curve analysis show that the area under the curve(AUC)of the above influencing factors were 0.899,0.637 and 0.654,respectively,with high sensitivity.Conclusion:The fluctuation of postoperative clinical symptoms in thrombolytic patients with ACI is related to the degree of stroke nerve defect,atrial fibrillation and infarction site.
Acute cerebral infarctionThrombolysisFluctuation of clinical symptomsInfluencing factors
万方数据
维普
