Effect of Low Molecular Weight Heparin and Aspirin in the Treatment of Patients with Recurrent Abortion and Influence for Coagulation Function and Miscarriage Prevention Effect
Objective:To explore and analyze the effect of Low Molecular Weight Heparin combined with Aspirin on coagulation function and miscarriage prevention in patients with recurrent abortion.Method:A total of 82 patients with recurrent abortion admitted to Maternal and Child Health Hospital in Shuangliu District of Chengdu City from January to December 2021 were selected and divided into control group and observation group according to random number table method,with 41 cases in each group.The control group was given Aspirin treatment,and the observation group was given Low Molecular Weight Heparin + Aspirin treatment.The miscarriage prevention effect,incidence of adverse reactions,hormone levels[progesterone(P),estradiol(E2)and β-human chorionic gonadotropin(β-hCG)],coagulation related indexes[antithrombin-Ⅲ(AT-Ⅲ),plasminogen activator inhibitor-1(PAI-1),D-dimer(D-D)]and thromboelastogram indexes before and after treatment were compared between the two groups.Result:The success rate of miscarriage prevention in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no statistically significant differences in hormone levels and coagulation related indexes between the two groups(P>0.05).At 12 and 20 weeks of gestation,the levels of P,E2,β-hCG,AT-Ⅲ,PAI-1 and D-D in the observation group were significantly better than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in thromboelastogram indexes between the two groups(P>0.05).At 12 and 20 weeks of gestation,the thromboelastogram indexes in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Low Molecular Weight Heparin and Aspirin therapy on recurrent abortion is better,and the coagulation function of patients can be significantly improved.
万方数据
维普
