Effect of Two Dosage Forms of Recombinant Human Interferon α2b in the Treatment of Cervical HPV Infection
Objective:To compare the effect of two dosage forms of Recombinant Human Interferon α2b in the treatment of cervical human papilloma virus(HPV)infection.Method:A total of 212 patients with cervical HPV infection admitted to Pucheng County Maternal and Child Health Care Hospital from April 2021 to January 2023 were selected.According to the method of random number table,the patients were divided into control group and experimental group,106 cases in each group.The control group was given Recombinant Human Interferon α2b Gel,and the experimental group was given Recombinant Human Interferon α2b Vaginal Effervescent Tablets.The clinical efficacy,immune function before and after treatment,safety and medication compliance were compared between the two groups.Result:The total effective rate of the experimental group was 79.25%(84/106),which was higher than 66.98%(71/106)of the control group,and the difference was statistically significant(P<0.05).After treatment,CD3+ and CD4+ increased and CD8+ decreased in both groups,and CD3+ and CD4+ in the experimental group were higher than those in the control group,while CD8+ was lower than that in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 7.55%(8/106),which was lower than 17.92%(19/106)in the control group,and the difference was statistically significant(P<0.05).The excellent and good rate of medication adherence in the experimental group was 93.40%(99/106),which was higher than 83.96%(89/106)in the control group,and the difference was statistically significant(P<0.05).Conclusion:Recombinant Human Interferon α2b Vaginal Effervescent Tablets is better than Recombinant Human Interferon α2b Gel in the treatment of cervical HPV infection,and the former has more obvious improvement in the immune function of patients,less adverse reactions,and higher medication compliance of patients.
Human papilloma virusRecombinant Human Interferon α2bGelEffervescent TabletsCompliance
万方数据
维普
