Objective:To analyze the effect of effect of hysteroscopic cold-knife micro-shear separation in patients with severe intrauterine adhesions(IUA)and its influence on serum indexes.Method:Eighty patients with severe IUA who admitted to the Department of Obstetrics and Gynecology,Huangzhou District People's Hospital,Huanggang City from January 2022 to January 2023 were selected by convenient sampling,and they were the divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was given hysteroscopic electrotomy and the observation group was given hysteroscopic cold-knife micro-shear separation.The clinical efficacy,menstrual improvement,endometrial arterial blood flow,endometrial thickness and serum indexes of two groups were compared.Result:The total effective rate in the observation group was 95.0%,which was higher than 77.5%in the control group,and the difference was statistically significant(P<0.05);the total effective rate of menstrual recovery in the observation group was 90.0%,which was higher than 72.5%in the control group,and the difference was statistically significant(P<0.05).At 30 d and 90 d after surgery,the endometrial arterial blood flow and endometrial thickness in two groups were significantly improved than those before surgery,and those in two groups at 90 d after surgery were better than those at 30 d after surgery,the resistant index(RI)and pulsatility(PI)in the observation group were lower than those in the control group,while the endometrial thickness was higher than that in the control group,the differences were statistically significant(P<0.05);at 30 d and 90 d after surgery,the serum indexes in two groups were significantly improved compared with those before surgery,and the serum indexes of two groups at 90 d after surgery were better than those at 30 d after surgery,and the levels of serum transforming growth factor-β1(TGF-β1),interleukin-6(IL-6)and plasminogen activator inhibitor-1(PAI-1)in the observation group were lower than those in the control group,while the level of matrix metalloproteinase-9(MMP-9)were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Hysteroscopic cold-knife micro-shear separation can achieve significant results in patients with severe IUA,which can not only improve the clinical efficacy and menstrual improvement effect,but also promote the recovery of endometrial artery blood flow and endometrial thickness,as well as effectively improve serum indexes.
维普
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