Value of Serum PCT,CRP and IL-4 Levels in Predicting the Severity of Mycoplasma Pneumonia in Children
Objective:To explore the value of serum procalcitonin(PCT),C reactive protein(CRP)and interleukin 4(IL-4)levels in predicting the severity of mycoplasma pneumonia in children.Method:A total of 102 children with mycoplasma pneumonia who treated in Huai'an Second People's Hospital from January 2019 to January 2023 were selected as the research objects,and they were divided into mild group 59 cases and severe group 43 cases according to their condition.The clinical data and the levels of stromal cell-derived factor(CXCL12),interferon-γ(IFN-γ),hydrogen sulfide(H2S),superoxide dismutase(SOD),matrix metalloproteinase-9(MMP-9),PCT,CRP and IL-4 were compared of two groups,and multivariate analysis was performed by unconditional logistic stepwise regression analysis.ROC curve was used to analyze the predictive value of PCT,CRP and IL-4 levels for severe mycoplasma pneumonia.Result:There were no significant differences in gender,age,course of disease and CXCL12,IFN-γ,H2S,SOD and MMP-9 levels between two groups(P>0.05);the levels of PCT,CRP and IL-4 in the severe group were significantly higher than those in the mild group,and the differences were statistically significant(P<0.05).logistic stepwise regression analysis showed that PCT,CRP and IL-4 were independent risk factors for severe mycoplasma pneumonia(P<0.05).ROC analysis showed that the area under the curve of PCT,CRP and IL-4 in predicting severe mycoplasma pneumonia were 0.896,0.851 and 0.787 respectively.Conclusion:Serum PCT,CRP and IL-4 levels are involved in the progression of children with mycoplasma pneumonia,and can be used as diagnostic indicators of severe mycoplasma pneumonia.
万方数据
维普
