Research Progress of Thalassemia Combined with Autoantibodies or Allogeneic Antibodies
Thalassemia is a severe progressive anemia that requires regular blood transfusion and iron chelator to reach life expectancy.One of the most important complications of blood transfusion is alloimmunity and autoimmunity,which increases the difficulty of blood matching and reduces the effect of blood transfusion.This article reviewed the incidence,diagnosis and clinical characteristics,blood transfusion and drug treatment of patients with thalassemia complicated with autoimmune hemolytic anemia,and analyzed the feasibility of red blood cell life span(RBCS)testing methods and their application in the patients with thalassemia complicated with autoimmune hemolytic anemia.
ThalassemiaAutoimmune hemolytic anemiaRed blood cell life span