阴道用乳杆菌活菌联合干扰素治疗子宫颈高危型HPV感染的效果及对阴道内环境影响的研究

Study on the Effect of Live Lactobacillus for Vaginal Use Combined with Interferon in the Treatment of Cervical High-risk HPV Infection and Its Influence on Vaginal Environment

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中文摘要：目的:探讨阴道用乳杆菌活菌联合干扰素治疗子宫颈高危型人乳头瘤病毒(HPV)感染的效果及对阴道内环境的影响.方法:选取 2022 年 3 月—2023 年 2 月广州市妇女儿童医疗中心(增城院区)收治的 180 例子宫颈高危型HPV感染患者,按随机数表法分为对照一组、对照二组和观察组,各 60 例.对照一组予以干扰素治疗;对照二组予以阴道用乳杆菌活菌治疗;观察组予以阴道用乳杆菌活菌联合干扰素治疗.评估三组临床疗效、阴道微生态、复发率及不良反应发生率.结果:观察组总有效率高于对照一组和对照二组,差异有统计学意义(P<0.05).治疗后,观察组阴道微生态环境正常、pH值正常、唾液酸酶阴性、过氧化氢阴性及白细胞酯酶阴性患者占比高于对照一组和对照二组,Nugent评分低于对照一组和对照二组,差异有统计学意义(P<0.05).观察组复发率低于对照一组和对照二组,差异有统计学意义(P<0.05).三组不良反应总发生率比较,差异无统计学意义(P>0.05).结论:阴道用乳杆菌活菌联合干扰素可提高子宫颈高危型HPV感染患者的治疗效果,改善患者的阴道微生态内环境,降低复发率.

外文摘要：Objective:To investigate the effect of Live Lactobacillus for Vaginal Use combined with Interferon in the treatment of cervical high-risk human papilloma virus(HPV)infection and its influence on the vaginal environment.Method:A total of 180 patients with high-risk cervical HPV infection admitted to Guangzhou Women and Children Medical Center Zengcheng Hospital from March 2022 to February 2023 were selected,and they were randomly divided into control group 1,control group 2 and observation group according to the random number table method,with 60 cases in each group.The control group 1 was treated with Interferon,the control group 2 was treated with Live Lactobacillus for Vaginal Use;observation group was treated with Live Lactobacillus for Vaginal Use combined with Interferon.The clinical efficacy,vaginal microecology,recurrence rate and adverse reaction rate of the three groups were evaluated.Result:The total effective rate of observation group was higher than that of control group 1 and control group 2,and the difference was statistically significant(P<0.05).After treatment,the proportion of patients with normal vaginal microecological environment,normal pH value,negative sialidase,negative hydrogen peroxide and negative leucocyte esterase in observation group were higher than those in control group 1 and control group 2,and the Nugent score was lower than that in control group 1 and control group 2,the differences were statistically significant(P<0.05).The recurrence rate of observation group was lower than that of control group 1 and control group 2,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P>0.05).Conclusion:Live Lactobacillus for Vaginal Use combined with Interferon can improve the clinical effect of high-risk cervical HPV infection,improve the vaginal microecological environment of patients,and reduce the recurrence rate.

外文关键词：

Cervical high-risk human papilloma virusLive Lactobacillus for Vaginal UseInterferonVaginal environmentNegative conversion rateRecurrence rateAdverse reaction

作者：

刘小燕、胡敏华、文依敏

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作者单位：

广州市妇女儿童医疗中心增城院区广东广州 511300

关键词：

子宫颈高危型人乳头瘤病毒阴道用乳杆菌活菌干扰素阴道内环境转阴率复发率不良反应

基金：

2021年度广州市增城区科技创新资金计划项目

项目编号：

2021ZCMS03

出版年：

2024

DOI：

10.14033/j.cnki.cfmr.2024.03.001

中外医学研究

中国医院管理杂志社

中外医学研究

影响因子：1.149

ISSN：1674-6805

年,卷(期)：2024.22(3)

参考文献量17