Explore the Relationship between Different Risk Degree of Down Syndrome,hCG Expression and Parturient Pregnancy Outcome
Objective:To analyze the pregnancy outcomes of parturient with different screened for Down syndrome risk and human chorionic gonadotropin(hCG)levels.Method:The clinical data of 583 parturients admitted to the Lipu Maternal and Child Health Hospital from January to December 2022 were retrospectively analyzed.The women were screened for Down syndrome in the second trimester of pregnancy,the fasting cubital vein blood samples were collected,the levels of hCG and alpha fetoprotein(AFP)were detected by chemiluminescence immunoassay,and the clinical data of the women were sorted out,and the risk was calculated by using the serological prenatal screening analysis software of Shanghai Tengcheng maternal in the second trimester of pregnancy.According to the calculation results,the parturients were divided into high risk group,critical risk group and low risk group.All parturients were followed up to the pregnancy outcome,and the pregnancy outcome of different parturients with Down syndrome risk were compared.The pregnancy outcomes of parturient with different hCG levels were also analyzed.Result:The age and weight of the low risk group were lower than those of the critical risk group and the high risk group,and the differences were statistically significant(P<0.05),while the follow-up of the three groups was not statistically significant(P>0.05).The incidence of gestational diabetes mellitus,premature rupture of membranes,cesarean section,macrosomia and pathological jaundice in low risk group were lower than those in critical risk group and high risk group,and the differences were statistically significant(P<0.05).The incidence of preterm birth,preeclampsia,premature rupture of membranes,placenta previa,fetal distress and stillbirth in the elevated group were higher than those in the normal group,the differences were statistically significant(P<0.05),while the incidence of preterm birth and preeclampsia in the decreased group were higher than those in the normal group,the differences were statistically significant(P<0.05).Conclusion:Down syndrome screening high risk,critical risk and abnormal expression of hCG not only suggest a higher risk of fetal aneuploid chromosome disease,but also associated with adverse pregnancy outcomes.
万方数据
维普
