The Diagnostic Value of Total Cholesterol and Homocysteine in Hypothyroidism
Objective:To investigate the diagnostic value of total cholesterol(TC)and homocysteine(Hcy)in hypothyroidism.Method:A total of 150 patients with hypothyroidism admitted to the Outpatient Department of Taizhou Maternity Hospital from July 2020 to June 2022 were retrospectively selected as the study group,and 90 patients with normal thyroid function were selected as the control group.Thyroid function indexes[thyroid stimulating hormone(TSH),total thyroxine(TT4)],TC and Hcy of the two groups were compared.Pearson correlation analysis was used to analyze the relationship between thyroid function indexes and TC and Hcy,and the diagnostic efficacy was evaluated by area under receiver(AUC)operating characteristic curve(ROC).Result:Serum TSH,TC and Hcy levels in the study group were higher than those in the control group,and serum TT4 levels was lower than that in the control group,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that TSH was positively correlated with TC and Hcy,while TT4 was negatively correlated with TC and Hcy(P<0.05).ROC analysis results showed that the AUC of single TC and Hcy levels and combined diagnosis of hypothyroidism were 0.748(95%CI:0.640,0.855),0.790(95%CI:0.669,0.911)and 0.819(95%CI:0.713,0.925),respectively.Conclusion:Hypothyroidism is positively correlated with TC and Hcy,and the combined diagnosis of TSH and TT4 levels has high value in diagnostic hypothyroidism.
Serum total cholesterolHomocysteine levelHypothyroidismThyroid stimulating hormoneTotal thyroxine
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