Characteristics and Expression of MRI Diffusion Weighted Imaging and HIF-1 in Neonates with HIE
Objective:To investigate the characteristics and expression of MRI diffusion weighted imaging and hypoxia-inducible factor-1(HIF-1)in neonates with hypoxic-ischemic encephalopathy(HIE).Method:The clinical data of 64 neonates with HIE admitted to the Xianning First People's Hospital from January 2018 to December 2022 were retrospectively analyzed.According to the severity of the disease,the children were divided into mild group(23 cases),moderate group(24 cases)and severe group(17 cases).MRI was performed in all three groups and HIF-1 levels were measured.MRI results and typical cases images of mild,moderate and severe children were analyzed.The levels of HIF-1 in children with different severity and different lesion types were compared.Result:The detection rate of MRI was 98.44%,and one case of missed diagnosis was a mild case.The level of HIF-1 in severe group and moderate group was higher than that in mild group,and the level of HIF-1 in severe group was higher than that in moderate group,the differences were statistically significant(P<0.05).The level of HIF-1 in children with basal ganglia injury and intracranial hemorrhage was significantly higher than that in children with simple brain edema,and the level of HIF-1 in children with intracranial hemorrhage was significantly higher than that in children with basal ganglia injury,the differences were statistically significant(P<0.05).Conclusion:MRI diffusion weighted imaging has a higher detection rate of neonates with HIE,and the HIE grade increases continuously,along with the serum HIF-1 expression level.
万方数据
维普
