Effects of Pramipexole Combined with Levodopa and Benserazide Hydrochloride on Cognitive Function,Oxidative Stress Indexes and Hcy in Patients with Parkinson Disease
Effects of Pramipexole Combined with Levodopa and Benserazide Hydrochloride on Cognitive Function,Oxidative Stress Indexes and Hcy in Patients with Parkinson Disease
Objective:To analyze the effects of Pramipexole combined with Levodopa and Benserazide Hydrochloride on cognitive function,oxidative stress indexes and Homocysteine(Hcy)in patients with Parkinson disease.Method:A total of 92 patients with Parkinson disease treated in the First People's Hospital of Suqian City from January 2020 to October 2022 were selected.They were randomly divided into control group and observation group,46 cases in each group.The control group was treated with Levodopa and Benserazide Hydrochloride,and the observation group was treated with Pramipexole on the basis of the control group.The cognitive function,oxidative stress indexes,Hcy before and after treatment and clinical efficacy of the two groups were compared.Result:After treatment,the mini-mental state examination scale(MMSE)scores of both groups were increased,and the MMSE score of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in both groups were increased,and the levels of GSH-Px and SOD in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,the Hcy level of the two groups decreased,and the Hcy level of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Pramipexole combined with Levodopa and Benserazide Hydrochloride can improve cognitive function and oxidative stress response in patients with Parkinson disease,and reduce Hcy level,has good clinical efficacy.
关键词
普拉克索/多巴丝肼/认知功能/帕金森病/氧化应激
Key words
Pramipexole/Levodopa and Benserazide Hydrochloride/Cognitive function/Parkinson disease/Oxidative stress
维普
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