目的:分析产科改良快速序贯器官衰竭评估(obstetrics meliorate quick-sequential organ failure assessment,omq-SOFA)评分、降钙素原(procalcitonin,PCT)与脓毒症病情严重程度及预后的关系.方法:选择2020年1月—2023年6月潜江市中心医院收治的 86 例脓毒症患者作为研究对象.入组 24 h内行国家早期预警评分(national early warning score,NEWS)、omq-SOFA评分和PCT检测.根据Sepsis-3.0 脓毒症诊断标准,将其分为脓毒症组(61 例)和严重脓毒症组(25 例);比较两组及不同NEWS评分患者omq-SOFA评分和PCT水平,使用Pearson相关性分析omq-SOFA评分和PCT与NEWS评分的相关性,比较不同预后患者omq-SOFA评分和PCT水平,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析omq-SOFA评分和PCT预测脓毒症预后的价值.结果:严重脓毒症组omq-SOFA评分、血清PCT水平均高于脓毒症组,差异有统计学意义(P<0.05).随着脓毒症患者NEWS评分升高,omq-SOFA评分、血清PCT水平随之升高,差异有统计学意义(P<0.05).Pearson相关性分析显示脓毒症患者omq-SOFA评分和PCT水平均与NEWS评分呈正相关(P<0.05).预后不良组omq-SOFA评分、血清PCT水平均高于预后良好组,差异有统计学意义(P<0.05).经ROC曲线分析,omq-SOFA评分、PCT预测脓毒症患者 28 d预后不良的曲线下面积(area under cruve,AUC)分别为 0.630、0.686,联合预测的AUC为0.921,大于单项指标的AUC,差异有统计学意义(P<0.05).结论:omq-SOFA评分和PCT有助于评估脓毒症病情严重程度,两者联合可以提高预测 28 d预后不良的准确性.
Analysis of the Relationship Between omq-SOFA Score,Procalcitonin and Sepsis Severity and Prognosis
Objective:To analyze the the relationship between obstetrics meliorate quick-sequential organ failure assessment(omq-SOFA)score,procalcitonin(PCT)and the severity and prognosis of sepsis.Method:A total of 86 patients with sepsis admitted to Qianjiang Central Hospital from January 2020 to June 2023 were selected as the study objects.National early warning score(NEWS),omq-SOFA score and PCT detection were performed within 24 h of enrollment.According to the diagnostic criteria of sepsis 3.0,patients were divided into sepsis group(61 cases)and severe sepsis group(25 cases).omq-SOFA score and PCT level were compared between the two groups and patients with different NEWS scores.Pearson correlation analysis was used to analyze the correlation between omq-SOFA score and PCT and NEWS score,omq-SOFA score and PCT level of patients with different prognosis were compared.Receiver operating characteristics(ROC)curve was used to analyze the value of omq-SOFA score and PCT in predicting the prognosis of sepsis.Result:omq-SOFA score and serum PCT level in severe sepsis group were higher than those in sepsis group,and the differences were statistically significant(P<0.05).omq-SOFA score and serum PCT level increased with the increase of NEWS score in patients with sepsis,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that omq-SOFA score and PCT level of sepsis patients were positively correlated with NEWS score(P<0.05).omq-SOFA score and serum PCT level in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).According to ROC curve analysis,the area under cruve(AUC)of omq-SOFA score and PCT for predicting poor prognosis of sepsis patients at 28 d were 0.630 and 0.686 respectively,the AUC of combined prediction was 0.921,which were greater than those of single indexes,the differences were statistically significant(P<0.05).Conclusion:omq-SOFA score and PCT can help to evaluate the severity of sepsis,and the combination can improve the accuracy of predicting the poor prognosis at 28 d.
SepsisObstetrics meliorate quick-sequential organ failure assessmentProcalcitoninPrognosis
万方数据
维普
