Clinical Effect of Low Dose Erythromycin Combined with Montelukast Sodium and Budesonide Inhalant in the Treatment of Refractory Asthma in Children
Objective:To study the clinical effect of low dose Erythromycin combined with Montelukast Sodium and Budesonide inhalant in the treatment of refractory asthma in children.Method:A total of 82 children with refractory asthma admitted to the First People's Hospital of Taicang City from January 2016 to December 2022 were selected,they were randomly divided into control group(n=40)and observation group(n=42).The control group was treated with Montelukast Sodium oral and Budesonide inhalant combined regimen,and the observation group was treated with low-dose Erythromycin on this basis.The patients were treated for 30 d.The clinical efficacy,symptom remission time,pulmonary function indexes and inflammatory immune markers before and after treatment were compared between the two groups.Result:Compared with the control group,the total effective rate of the observation group was higher,and the difference was statistically significant(P<0.05).Compared with the control group,the remission time of cough and wheezing in the observation group were shorter,and the differences were statistically significant(P<0.05).There were no significant differences in pulmonary function between the two groups before treatment(P>0.05).After treatment,pulmonary function was improved in both groups,the levels of forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),peak expiratory flow(PEF),instantaneous flow rate of 75%forced expiratory flow(FEF75)and maximal mid-expiratory flow curve(MMEF)in the observation group were higher,the differences were statistically significant(P<0.05).There were no significant differences in the levels of eosinophils,immunoglobulin G(IgG)and immunoglobulin E(IgE)between the two groups before treatment(P>0.05).After treatment,the levels of eosinophils,IgG and IgE in both groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion:The use of low-dose Erythromycin combined with Montelukast Sodium and Budesonide inhalants in the treatment of refractory asthma in children can significantly improve clinical efficacy,improve pulmonary function indicators,reduce inflammatory and immune markers.
万方数据
维普
