Preventive Effects of Dexmedetomidine on Postoperative Delirium and Adverse Reactions in Elderly Patients Undergoing Joint Replacement
Objective:To investigate the preventive and therapeutic effects of Dexmedetomidine on postoperative delirium in elderly joint replacement patients.Method:Sixty patients who received joint replacement treatment in Suzhou Yongding Hospital from January 2018 to June 2023 were selected,and they were randomly divided into experimental group and control group,with 30 patients in each group.Both groups underwent combined epidural anesthesia.Before combined epidural anesthesia and during surgery,the experimental group was injected with Dexmedetomidine and the control group was injected with 0.9%Sodium Chloride Injection.Hemodynamic indexes(heart rate,mean arterial pressure)at different time points,postoperative delirium and adverse reactions were compared between the two groups.Result:The heart rate and mean arterial pressure of the control group at 5 min and 30 min at the beginning of operation were higher than those before operation,and the differences were statistically significant(P<0.05).The heart rate and mean arterial pressure of the experimental group were lower than those of the control group at 5 min and 30 min after operation,and the differences were statistically significant(P<0.05).The total incidence of delirium and adverse reactions in experimental group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion:Dexmedetomidine is helpful to stabilize hemodynamics and reduce postoperative delirium and adverse reactions in elderly patients undergoing joint replacement surgery.
万方数据
维普
