药物性肝损伤(drug-induced live injury，DILI)是指由各类处方或非处方的化学药物、生物制剂、传统中药、天然药、保健品、膳食补充剂及其代谢产物乃至辅料等所诱发的肝损伤。DILI是最常见和最严重的药物不良反应之一，轻度可导致患者肝酶浓度升高，早期诊治预后较好;重度则造成患者不可逆转的肝移植甚至死亡。针对当前具有潜在肝毒性的药物种类繁多、个体差异性导致的发病机制复杂及临床上鉴别诊断该疾病的困难性等问题，寻找简便客观、特异度高、敏感度强的诊断指标具有重要的应用价值。本文综述了DILI的相关信息，包括传统的标准化鉴别诊断、具有潜力的新型诊断标志物及与诊断相关的新型辅助方法，以期为未来DILI的鉴别诊断提供更加有效的帮助。
Research Progress of Diagnostic Strategies for Drug-induced Liver Injury
Drug-induced liver injury(DILI)refers to liver injury induced by various types of prescription or non-prescription chemical drugs,biologicals,traditional Chinese medicine,natural drugs,nutraceuticals,dietary supplements and their metabolites and even excipients,etc.DILI is one of the most common and serious adverse drug reactions,which can lead to elevated liver enzyme concentrations in mild cases with a better prognosis for early diagnosis and treatment,and in severe cases resulting in irreversible in severe cases,it can lead to irreversible liver transplantation or even death.The variety of drugs with potential hepatotoxicity,the complexity of the pathogenesis due to individual differences and the difficulty of differential diagnosis of the disease in clinical practice make it important to find simple,objective,specific and sensitive diagnostic indicators.This article reviewed information on DILI,including traditional standardized differential diagnosis,promising new diagnostic markers,and novel methods related to diagnosis,with the aim of providing more effective assistance in the differential diagnosis of DILI in the future.
万方数据
维普
