Effect of Low Molecular Weight Heparin Anticoagulant Therapy on Sepsis Patients
Objective:To explore the effects of Low Molecular Weight Heparin anticoagulant therapy on sepsis patients.Method:The clinical data of 78 patients with sepsis admitted to the Zunyi First People's Hospital and Hunan Provincial People's Hospital from December 2022 to August 2023 were retrospectively analyzed.They were divided into two groups according to different treatment methods,with 39 cases in each group.The control group was given conventional treatment,and the observation group was given Low Molecular Weight Heparin on the basis of the control group.The health status,serum inflammatory factors,coagulation function,vascular endothelial function,thromboelastogram index and adverse reactions were compared between the two groups.Result:After treatment,acute physiological and chronic health evaluation status(APACHEⅡ)scores in both groups was lower than that before treatment,and observation group was lower than that in control group,the differences were statistically significant(P<0.05).After treatment,the procalcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP),activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer,thrombomodulin(TM)and thrombine-antithrombin complex(TAT),tissue plasminogen activator-inhibitor-complex(t-PAI-C)in two groups were significantly lower than those before treatment,and the indexes in the observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,maximum amplitude(MA),blood coagulation time(K),coagulation reaction time(R),coagulation angle(α)in two groups were significantly higher than those before treatment,and the indexes in the observation group were higher than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Anticoagulant treatment of Low Molecular Weight Heparin in sepsis patients can effectively reduce the level of serum inflammatory factors,improve vascular endothelial function,coagulation function and thromboelastogram index,and improve the health status of patients with high safety.
SepsisLow Molecular Weight HeparinAnticoagulant therapyInflammatory responseVascular endothelial function
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