Study on the Expression Change of Lesion Tissue CK7,HER2,MLH1,MSH2 and MSH6 of Patients with Gastric Cancer
Objective:To investigate the expression changes of cytokeratin 7(CK7),human epidermal growth factor receptor-2(HER2),mismatch repair protein MutL homolog 1(MLH1),mismatch repair protein MutS homolog 2(MSH2)and mismatch repair protein MutS homolog 6(MSH6)in focal tissues of gastric cancer patients.Method:A total of 120 patients with gastric cancer admitted to Suzhou Xiangcheng People's Hospital from February 2020 to January 2023 were selected as the study objects,the expression of CK7,HER2,MLH1,MSH2 and MSH6 in lesion tissues and adjacent tissues were compared.The expression of CK7,HER2,MLH1,MSH2 and MSH6 in focal tissues of patients with different sex,age,TNM stage,differentiation degree,lymph node metastasis and focal location were compared.Result:The positive rate of CK7 and HER2 and the deletion rate of MLH1,MSH2 and MSH6 expression in focal tissues of gastric cancer patients were significantly higher than those in adjacent tissues,the differences were statistically significant(P<0.05).There were no significant differences in the expression of CK7,HER2,MLH1,MSH2 and MSH6 in focal tissues of different sex,age and lesion location(P>0.05).The positive rates of CK7 and HER2 in focal tissues of stage Ⅲ and stage Ⅳ were higher than those in stage Ⅰand stage Ⅱ,and the expression deletion rates of MLH1,MSH2 and MSH6 were significantly lower than those in stage Ⅰ and stage Ⅱ,the differences were statistically significant(P<0.05).The positive rates of CK7 and HER2 in the lesion tissues with low differentiation were significantly higher than those with high differentiation,and the expression deletion rates of MLH1,MSH2 and MSH6 were significantly lower than those with high differentiation,the differences were statistically significant(P<0.05).The positive rates of CK7 and HER2 in patients with lymph node metastasis were significantly higher than those without lymph node metastasis,and the expression deletion rates of MLH1,MSH2 and MSH6 were significantly lower than those without lymph node metastasis,the differences were statistically significant(P<0.05).Conclusion:The expression of CK7,HER2,MLH1,MSH2 and MSH6 in focal tissues of gastric cancer patients was relatively abnormal,and there were significant differences in different TNM stages,degrees of differentiation and lymph node metastasis.
Gastric cancer Lesion tissueParacancerous tissueCytokeratin 7Human epidermal growth factor receptor-2Mismatch repair protein MutL homolog 1Mismatch repair protein MutS homolog 2Mismatch repair protein MutS homolog 6
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