Distribution Characteristics and Drug Resistance of Carbapenem-resistant Enterobacteriaceae Bacteria in a Hospital from 2019 to 2022
Objective:To investigate the distribution and drug resistance of carbapenem-resistant enterobacteriaceae(CRE)bacteria in a hospital from 2019 to 2022.Method:A total of 7633 strains of Enterobacteriaceae from Nanjing Gaochun People's Hospital from January 2019 to December 2022 were selected for identification and drug sensitivity test,and the distribution characteristics and drug resistance of CRE were statistically analyzed.Result:Among the 7633 strains of Enterobacteriaceae,115 strains of CRE accounted for 1.51%,including 63 strains of Klebsiella pneumoniae,10 strains of Serratia marcescens,35 strains of Escherichia coli,3 strains of Enterobacter cloacae,3 strains of Enterobacter aerogenes and 1 strain of Klebsiella acidophilus.The 115 strains of CRE were isolated from hospitalized patients,including 41 strains(35.65%)in Intensive Care Unit,22 strains(19.13%)in Rehabilitation Department,12 strains(10.43%)in Oncology Department,7 strains each in Respiratory Department and other departments,6 strains each in Urology Department,Neurosurgery Department and General Surgery Department,3 strains each in Neurology Department and Infectious Department,and 2 strains in Gastroenterology Department.The 115 strains of CRE were isolated from sputum with 42 strains(36.52%),urine with 41 strains(35.65%)and secretion with 13 strains(11.30%).Klebsiella pneumoniae showed high resistance to Cefepime,and Escherichia coli showed high resistance to Piperacillin,Serratia marcescens showed high resistance to Ampicillin and Piperacillin,and Enterobacter cloacae showed high resistance to Cefepime,Enterobacter aerogenes showed resistance to Cefepime and Ceftazidime,and Klebsiella acidophilus showed resistance to Ceftazidime.Conclusion:Klebsiella pneumoniae and Escherichia coli are the main CRE,and the sensitivity rate of CRE to most commonly used antibiotics is low.Clinical surveillance of nosocomial infection should be done well,and antibiotics should be used rationally,so as to effectively prevent and control the production and spread of drug-resistant strains.
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