Effect of Epalrestat Combined with Butylphthalide Soft Capsules on Patients with Painful Diabetic Peripheral Neuropathy
Objective:To analyze the effect of Epalrestat combined with Butylphthalide Soft Capsules on patients with painful diabetic peripheral neuropathy(PDPN).Method:A total of 80 patients with PDPN who admitted to Tongcheng County People's Hospital from February 2021 to February 2022 were selected as the study objects,and the patients were divided into the study group and the control group according to the coin toss method,with 40 patients in each group.The control group was given Epalrestat,and the study group was given Butylphthalide Soft Capsules on the basis of the control group.The clinical efficacy,adverse reactions,pain degree[visual analogue scale(VAS)],sensory nerve conduction velocity(SNCV),motor nerve conduction velocity(MNCV)of median nerve,common peroneal nerve and ulnar nerve and oxidative stress index[superoxide dismutase(SOD),malondialdehyde(MDA)]levels were compared between two groups.Result:The total effective rate of the study group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).After 1 month of treatment,the VAS scores of two groups were lower than those before treatment,and that in the study group was lower than that in the control group,the differences were statistically significant(P<0.05).After 1 month of treatment,the SNCV and MNCV of median nerve,common peroneal nerve and ulnar nerve in two groups increased compared with those before treatment,and which in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).After 1 month of treatment,the levels of SOD and MDA in two groups were improved compared with those before treatment,and the level of SOD in the study group was higher than that in the control group,and the level of MDA was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Epalrestat combined with Butylphthalide Soft Capsules in the treatment of PDPN has a better clinical effect,which can significantly reduce the degree of pain after treatment it can effectively improve SNCV and MNCV of median nerve,common peroneal nerve and ulnar nerve,and reduce SOD and MDA levels.
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