Diagnostic Value of Total Bilirubin/Albumin Ratio,Hearing Screening and MRI-T1WI Imaging in Neonatal with Acute Bilirubin Encephalopathy
Objective:To explore the diagnostic value of total bilirubin/albumin ratio(B/A),hearing screening and magnetic resonance image-T1-weighted imaging(MRI-T1WI)in neonatal with acute bilirubin encephalopathy(ABE).Method:A total of 136 neonatal hyperbilirubinemia(NHB)children treated in Taicang First People's Hospital from June 2013 to June 2023 were selected as the study objects,and they were divided into the concurrent group(n=42)and the control group(n=94)according to whether neonatal ABE was complicated.The clinical data,B/A levels,hearing screening results,and pallidus T1WI signal intensity of the two groups were compared.Multivariate logistic regression analysis was performed for the indicators that had significance in univariate analysis,and ROC curve was used to analyze their diagnostic value in neonatal with ABE.Result:The peak value of total serum bilirubin(TSB)and B/A level in concurrent group were higher than those in control group,the differences were statistically significant(P<0.05).The rate of hearing abnormality in the concurrent group was 38.10%at the first screening,and 35.71%at the re-screening,both higher than 18.09%and 8.51%in the control group,and the differences were statistically significant(P<0.05).The ratio of T1WI signal intensity between globus pallidus and frontal cortex(G/Gr)of the concurrent group was higher than that of the control group,and the difference was statistically significant(P<0.05).logistic regression analysis showed that B/A,hearing abnormality and G/Gr level were independent risk factors for ABE in NHB children,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC values of B/A,G/Gr,hearing abnormality and their combined detection of NHB complicated ABE were 0.773,0.652,0.754 and 0.863,respectively,which had high diagnostic value,and the combined diagnosis value was the highest(P<0.05).Conclusion:The expression levels of B/A,hearing abnormality and G/Gr in children with ABE were significantly increased,and the three alone and combined detection of NHB complicated ABE in children had high diagnostic value,and the combined diagnosis effect of the three was the best.
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