Effect of Modified Qingwen Baidu Decoction Combined with CRRT in the Treatment of Sepsis Complicated with Severe Pneumonia with Phlegm Toxin Accumulation in the Lung Syndrome
Objective:To analyze the effect of modified Qingwen Baidu Decoction combined with continuous renal replacement therapy(CRRT)on sepsis complicated with severe pneumonia(SP)with phlegm toxin accumulation in the lung syndrome.Method:Prospective study was conducted in 68 patients with sepsis complicated with SP with phlegm toxin accumulation in the lung syndrome admitted to Sanming Hospital of Integrated Traditional Chinese and Western Medicine from June 2020 to September 2022,and they were divided into two groups according to random number table method,with 34 cases in each group.The control group was treated with CRRT,and the observation group was treated with modified Qingwen Baidu Decoction on the basis of control group.The therapeutic effect,blood gas index,serum inflammatory factor level,duration of intensive care,mortality rate at 28 d after treatment and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of treatment in the observation group was 97.06%,which was higher than 76.47%in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood oxygen pressure(PaO2)of the two groups were higher than those before treatment,and the carbon dioxide pressure(PaCO2)were lower than those before treatment,and the PaO2 of the observation group was higher than that of the control group,and the PaCO2 was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6),procalcitonin(PCT),and C-reactive protein(CRP)in the two groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The mortality rate at 28 d after treatment of the observation group was 0,which was lower than 5.88%in the control group,but there was no statistically significant difference between the two groups(P>0.05).The duration of intensive care in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.88%,which was lower than 23.53%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Modified Qingwen Baidu Decoction combined with CRRT has a good effect in the treatment of patients with sepsis complicated with SP with phlegm toxin accumulation in the lung syndrome,which can significantly improve blood gas indexes and inflammatory state of patients,shorten the duration of intensive care,and reduce the occurrence of adverse reactions.
Qingwen Baidu DecoctionContinuous renal replacement therapySepsisSevere pneumoniaPhlegm toxin accumulation in the lung syndrome
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