Effect of Bushen Tongmai Prescription on Coagulation and Fibrinolysis System and Blood Lipid after PCI of Acute ST Segment Elevation Myocardial Infarction
Objective:To observe the effects of Bushen Tongmai Prescription on coagulation and fibrinolysis system and blood lipid after percutaneous coronary intervention(PCI)of acute ST segment elevation myocardial infarction.Method:Ninety-two patients with acute ST-segment elevation myocardial infarction admitted to Xuzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from March 2017 to March 2020 were selected,and they were divided into control group and treatment group according to random grouping method,with 46 cases in each group.All enrolled patients were given standardized medical treatment,and Bushen Tongmai Prescription was added to the treatment group on the basis of standard treatment.The changes of fibrinogen(FIB),antithrombin Ⅲ(AT-Ⅲ),tissue type plasminogen activator(t-PA),plasminogen activator inhibitor 1(PAI-1),soluble leukocyte differentiation antigen 40 ligand(sCD40L),soluble intercellular adhesion factor-1(sICAM-1)and blood lipid before and after treatment were observed in the two groups.Result:Before treatment,there were no significant differences in FIB,AT-Ⅲ,t-PA and PAI-1 levels between the two groups(P>0.05).After treatment,FIB and PAI-1 levels decreased,AT-Ⅲ and t-PA levels increased,FIB and PAI-1 levels in the treatment group were lower than those in the control group,while AT-Ⅲ and t-PA levels were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in sCD40L and sICAM-1 levels between the two groups(P>0.05).After treatment,the levels of sCD40L and sICAM-1 in both groups decreased significantly,and the levels of sCD40L and sICAM-1 in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)between two groups(P>0.05).After treatment,the levels of TC,TG and LDL-C were significantly decreased in both groups,and HDL-C were increased,the levels of TC,TG and LDL-C in the treatment group were lower than those in the control group,while the level of HDL-C was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:On the basis of standard medical treatment,Bushen Tongmai Prescription can improve the hypercoagulable state of patients with acute ST segment elevation myocardial infarction after PCI,regulate the balance of coagulation and fibrinolysis system in patients,control the inflammatory response,and reduce the level of blood lipid.
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