Comparison of the Effects of Propylthiouracil and Thiamazole in the Treatment of Hyperthyroidism
Objective:To analyze and compare the efficacy of Propylthiouracil and Thiamazole in the treatment of hyperthyroidism.Method:A total of 100 hyperthyroidism patients admitted to Guizhou Panjiang Coal and Electricity Group Co.,Ltd.Hospital from April 2021 to June 2023 were randomly divided into two groups,with 50 cases in each group.The control group was treated with Propylthiouracil and the experimental group was treated with Thiamazole.The therapeutic effect,thyroid function index,liver function index and the occurrence of adverse reactions were compared between the two groups.Result:After treatment,the total effective rate of experimental group was significantly higher than that of control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in thyroid function indexes between the two groups(P>0.05).After treatment,free triiodothyronine(FT3)and free tetraiodothyronine(FT4)in two groups were lower than those before treatment,and thyroid stimulating hormone(TSH)were higher than those before treatment,and FT3 and FT4 in experimental group were lower than those in control group,and TSH was higher than that in control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in liver function indexes between the two groups(P>0.05).After treatment,total bilirubin(TBIL),alkaline phosphatase(ALP)and alanine aminotransferase(ALT)in two groups were higher than those before treatment,but those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in experimental group was significantly lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion:The treatment of hyperthyroidism with Thiamazole has achieved remarkable results,which can effectively improve the thyroid function of patients with less damage to the liver and lower adverse reaction rate,and is safer and more effective than Propylthiouracil.
PropylthiouracilThiamazoleHyperthyroidismEffectAdverse reactionsThyroid functionLiver function
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