首页|注射用复方甘草酸单铵S联合恩替卡韦治疗慢性乙型病毒性肝炎的效果及对患者肠道菌群的影响

注射用复方甘草酸单铵S联合恩替卡韦治疗慢性乙型病毒性肝炎的效果及对患者肠道菌群的影响

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的:探讨注射用复方甘草酸单铵S联合恩替卡韦治疗慢性乙型病毒性肝炎患者的效果及对肠道菌群的影响。方法:选取 2021 年 1 月—2022 年 7 月毕节市中医医院收治的 82 例慢性乙型病毒性肝炎患者作为观察对象。按照入院时间顺序分组，将 2021 年 1-10 月收治的患者纳入对照组，2021 年 11 月—2022 年 7 月收治的患者纳入观察组，各 41 例。对照组采用恩替卡韦单独治疗，观察组则采用恩替卡韦联合注射用复方甘草酸单铵S治疗。观察两组总有效率，并分析治疗前后肝纤维化指标水平、肠道菌群数量。结果:治疗后，观察组总有效率为 92。68%，高于对照组的 75。61%，差异有统计学意义(P<0。05)。治疗后，观察组透明质酸酶(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)低于对照组，差异有统计学意义(P<0。05)。治疗后，观察组肠球菌、大肠杆菌数量少于对照组，乳酸杆菌、双歧杆菌、拟杆菌数量多于对照组，差异有统计学意义(P<0。05)。结论:应用恩替卡韦联合注射用复方甘草酸单铵S治疗慢性乙型病毒性肝炎患者，可有效降低肝纤维化指标水平，平衡肠道菌群数量，疗效显著。
Effect of Compound Ammonium Glycyrrhetate S for Injection Combined with Entecavir in the Treatment of Chronic Viral Hepatitis B and Its Effect on Intestinal Flora of Patients
Objective:To explore the effect of Compound Ammonium Glycyrrhetate S for Injection combined with Entecavir in the treatment of chronic viral hepatitis B patients and the effect on intestinal flora.Method:A total of 82 patients with chronic viral hepatitis B treated in Bijie Hospital of Traditional Chinese Medicine from January 2021 to July 2022 were selected as the observation objects.Patients admitted from January to October 2021 were included in the control group,and those admitted from November 2021 to July 2022 were included in the observation group,with 41 cases in each group.The control group was treated with Entecavir alone,and the observation group was treated with Entecavir combined with Compound Ammonium Glycyrrhetate S for Injection.The total effective rate of the two groups was observed,and the liver fibrosis index level and intestinal flora number before and after treatment were analyzed.Result:After treatment,the total effective rate of observation group was 92.68%,which was higher than 75.61%of control group,the difference was statistically significant(P<0.05).After treatment,hyaluronidase(HA),laminin(LN),type Ⅲ procollagen(PC-Ⅲ)and typeⅣ collagen(Ⅳ-C)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the number of Enterococcus and Escherichia coli in observation group were less than those in control group,while the number of Lactobacillus,Bifidobacterium and Bacteroides in observation group were more than those in control group,the differences were statistically significant(P<0.05).Conclusion:Entecavir combined with Compound Ammonium Glycyrrhetate S for Injection in the treatment of chronic viral hepatitis B patients can effectively reduce the level of liver fibrosis indexes and balance the number of intestinal flora,with significant efficacy.

EntecavirCompound Ammonium Glycyrrhetate S for InjectionChronic viral hepatitis B

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毕节市中医医院 贵州 毕节 551700

恩替卡韦 注射用复方甘草酸单铵S 慢性乙型病毒性肝炎

2024

10.14033/j.cnki.cfmr.2024.05.027

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子：1.149
ISSN：1674-6805
年,卷(期)：2024.22(5)
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