亚甲蓝注射液治疗感染性休克的效果
Effect of Methylene Blue Injection in the Treatment of Septic Shock
张敏仪 1陈继桃 1苏薇 1王家玲 1陈海林 1利鸿胜 1吴育宇1
作者信息
- 1. 茂名市人民医院 广东 茂名 525000
- 折叠
摘要
目的:研究亚甲蓝(Methylene Blue,MB)注射液治疗感染性休克的效果.方法:选取 2021 年 7 月—2022 年6 月茂名市人民医院收治的 80 例感染性休克患者为研究对象.根据随机数表法将其分为对照组和观察组,各 40 例.对照组给予常规治疗,观察组在对照组基础上给予MB注射液.比较两组治疗前(T0)、治疗 1 d后(T1)、治疗 3 d后(T2)、治疗 5 d后(T3)、治疗 7 d后(T4)的平均动脉压(mean arterial pressure,MAP)、心率(heart rate,HR)、外周血管阻力指数(systemic vascular resistance index,SVRI)、肺血管阻力指数(pulmonary vascular resistance index,PVRI)、心脏指数(cardiac index,CI)及无创脉搏氧灌注指数(noninvasive pulse oxygen perfusion index,PI),治愈率及不良反应.结果:T2、T3、T4,观察组MAP、HR、SVRI、PVRI、CI、PI均高于对照组,差异有统计学意义(P<0.05).观察组的治愈率为 85.00%(34/40),高于对照组的 62.50%(25/40),差异有统计学意义(x2=5.230,P=0.022).观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05).结论:MB注射液治疗感染性休克能够获得更高的治愈率,有效改善患者机体的血流动力学,治疗安全性较好.
Abstract
Objective:To study the effect of Methylene Blue(MB)Injection in the treatment of septic shock.Method:A total of 80 patients with septic shock admitted to Maoming People's Hospital from July 2021 to June 2022 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received conventional treatment,and the observation group received MB Injection on the basis of the control group.The mean arterial pressure(MAP)and heart rate(heart rate),systemic vascular resistance index(SVRI),pulmonary vascular resistance index(PVRI),cardiac index(CI),noninvasive pulse oxygen perfusion index(PI)before treatment(T0),after 1 d of treatment(T1),after 3 d of treatment(T2),after 5 d of treatment(T3)and after 7 d of treatment(T4),cure rate and adverse reactions of the two groups were compared.Result:T2,T3,T4,MAP,HR,SVRI,PVRI,CI,PI in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).The cure rate of observation group was 85.00%(34/40),which was higher than 62.50%(25/40)of control group,the difference was statistically significant(x2=5.230,P=0.022).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:MB Injection in the treatment of septic shock can obtain a higher cure rate,effectively improve the patient's body hemodynamics,treatment safety is good.
关键词
感染性休克/亚甲蓝/治愈率/临床效果/安全性/生命体征Key words
Septic shock/Methylene Blue/Cure rate/Clinical effect/Security/Vital sign引用本文复制引用
基金项目
茂名市科技计划项目(210327154550477)
出版年
2024
国家科技期刊平台
NSTL
万方数据