Clinical Efficacy of Atorvastatin Calcium Combined with Hyperbaric Oxygen in the Treatment of Subdural Effusion after Craniotomy for Severe Traumatic Brain Injury
Objective:To investigate the clinical effect of Atorvastatin Calcium combined with hyperbaric oxygen in the treatment of subdural effusion(SE)after craniotomy in patients with severe traumatic brain injury(SBI).Method:A total of 76 patients with SE after SBI craniotomy admitted to the Neurosurgery Department of Jieyang City People's Hospital from June 2022 to October 2023 were selected as the study objects,and they were divided into group A and group B by database randomization method,with 38 cases in each group.Group A was treated with hyperbaric oxygen,group B was treated with Atorvastatin Calcium combined with hyperbaric oxygen.Treatment effective rate,incidence of complication,test indicators,National Institutes of Health stroke scale(NIHSS)score,clinical indicators,and the MOS item short from health survey(SF-36)score were compared between the two groups.Result:The treatment total effective rate of group B was higher than that of group A,the difference was statistically significant(P<0.05),the complication rate of group B was lower than that of group A,but there was no statistically significant difference between the two groups(P>0.05).After treatment,hypersensitive C-reactive protein(hs-CRP),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triacylglycerol(TG)and total cholesterol(TC)in both groups were better than those before treatment,and the above indexes in group B were better than those in group A,the differences were statistically significant(P<0.05).After treatment,NIHSS scores in both groups were lower than those before treatment,and that in group B was lower than that in group A,the differences were statistically significant(P<0.05).After treatment,the amount of subdural effusion in the two groups were less than those before treatment,and that in group B was less than that in group A,the differences were statistically significant(P<0.05).The time to return to normal intracranial pressure and hospital stay in group B were shorter than those in group A,and the hospitalization cost was less than that in group A,the differences were statistically significant(P<0.05).After treatment,SF-36 scores in both groups were higher than those before treatment,and those in group B were higher than those in group A,the differences were statistically significant(P<0.05).Conclusion:Atorvastatin Calcium combined with hyperbaric oxygen is effective in the treatment of SE patients after SBI craniotomy,which can improve nerve function,promote rapid fluid absorption,shorten rehabilitation time,reduce treatment cost,improve quality of life,and have high safety.
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