目的:探讨神经内镜联合颅底显微神经外科手术(cranial base micro neurosurgery，CBM)对脑肿瘤患者的影响。方法:选取 2018 年 1 月—2022 年 12 月灵山县人民医院收治的 60 例脑肿瘤患者。根据单双号将其平分为试验组和对照组，各 30 例。对照组实施CBM治疗，试验组实施神经内镜联合CBM治疗。比较两组肿瘤切除情况及围手术期指标，术前、术后神经功能及日常生活能力、相关指标，并发症及治愈率。结果:试验组完全切除率为 96。67%，高于对照组的 80。00%，手术时间、住院时间均短于对照组，差异有统计学意义(P<0。05)。术后，试验组美国国立卫生研究院卒中量表(National Institute of Health stroke scale，NIHSS)评分低于对照组，日常生活能力量表(activities of daily living，ADL)评分高于对照组，差异有统计学意义(P<0。05)。术后，试验组白细胞介素-6(interleukin-6，IL-6)、S-100β蛋白(S-lfln protein 100β，S100β)及肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)水平均低于对照组，差异有统计学意义(P<0。05)。试验组并发症发生率低于对照组，治愈率高于对照组，差异有统计学意义(P<0。05)。结论:神经内镜联合CBM可以提高脑肿瘤无全切除率，改善其神经功能及生活能力，降低炎症因子水平，治愈率高，并发症少，住院时间短，预后好，安全性高。
Effect of Neuroendoscopy Combined with Cranial Base Micro Neurosurgery on Patients with Brain Tumor
Objective:To investigate the effect of neuroendoscopy combined with cranial base micro neurosurgery(CBM)on patients with brain tumor.Method:A total of 60 patients with brain tumor treated in Lingshan County People's Hospital from January 2018 to December 2022 were selected.According to the odd-even number,they were divided into experimental group and control group,30 cases in each group.The control group was treated with CBM,and the experimental group was treated with neuroendoscopy combined with CBM.The tumor resection condition and perioperative indexes,preoperative and postoperative nerve function and daily living ability,related indexes,complications and cure rate were compared between the two groups.Result:The total resection rate of the experimental group was 96.67%,which was higher than 80.00%of the control group,and the operation time and hospital stay were shorter than those of the control group,the differences were statistically significant(P<0.05).After surgery,the National Institute of Health stroke scale(NIHSS)score of the experimental group was lower than that of the control group,and the activities of daily living scale(ADL)score was higher than that of the control group,and the differences were statistically significant(P<0.05).After surgery,the levels of interleukin-6(IL-6),S-lfln protein 100β(S100β)and tumor necrosis factor-α(TNF-α)in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).The incidence of complication of experimental group was lower than that in control group,and the cure rate was higher than that in control group,the differences were statistically significant(P<0.05).Conclusion:Neuroendoscopy combined with CBM can increase the total resection rate of brain tumor,improve the neurological function and life ability,reduce the level of inflammatory factors,with high cure rate,fewer complications,short hospital stay,good prognosis and high safety.
Brain tumorNeuroendoscopyCranial base micro neurosurgery
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