Effect of Nicorandil on Cardiac Function and Adverse Cardiovascular Events in Patients with ST Segment Elevation Myocardial Infarction after PCI
Objective:To investigate the effect of Nicorandil on cardiac function and adverse cardiovascular events in patients with ST segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Method:A total of 76 STEMI patients who admitted to Affiliated Hospital of Putian University from June 2020 to June 2022 were selected as the study objects,and they were divided into the control group and the observation group according to the random number table method,with 38 patients in each group.Two groups were treated with conventional antiplatelet and antihypertensive drugs before operation,and the control group was treated with conventional PCI,while the observation group was additional given Nicorandil on the basis of the control group.The cardiac function,inflammatory factor levels and major adverse cardiovascular events(MACE)between two groups were compared.Result:At 6 months after operation,the left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic volume index(LVESVI)in two groups were lower than those before operation,and the left ventricular ejection fraction(LVEF)and peak ejection rate(PER)were higher than those before operation,the differences were statistically significant(P<0.05);compared with the control group,the observation group had lower LVEDD and LVESVI,higher LVEF and PER at 6 months after operation,and the differences were statistically significant(P<0.05).At 6 months after operation,the levels of myeloperoxidase(MPO),C-reactive protein(CRP),interleukin-6(IL-6)and B-type brain natriuretic peptide(BNP)in two groups were lower than those before operation,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).Compared with the control group,the observation group had a lower overall incidence of MACE at 6 months after surgery,the difference was statistically significant(P<0.05).Conclusion:Nicorandil is effective in the treatment of STEMI patients after PCI,which is beneficial to improve the postoperative cardiac function index,reduce the level of inflammatory factors,and the incidence of MACE is low.
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