Effect of Progressive Decompression During Large Bone Flap Decompression in the Treatment of Severe Craniocerebral Injury and Its Effect on BNP,t-PA and PAI-1 Levels
Objective:To investigate the effect of progressive decompression during large bone flap decompression in the treatment of severe craniocerebral injury and the effect on serum brain natriuretic peptide(BNP),tissue type plasminogen activator(t-PA)and plasminogen activator inhibitor-1(PAI-1)levels.Method:A total of 98 patients with severe craniocerebral injury admitted to the First Affiliated Hospital of Anhui Medical University from February 2020 to February 2023 were selected as the study objects,and they were divided into control group and observation group according to random number table method,with 49 cases in each group.Both groups were treated with large bone flap decompression.The control group was treated with conventional decompression,and the observation group was treated with progressive decompression.Serum related indexes,intracranial pressure,consciousness level and postoperative complications were compared between the two groups.Result:At 1 d after surgery,BNP in the two groups were higher than those before surgery,PAI-1 and t-PA levels were lower than those before surgery,and BNP,PAI-1 and t-PA levels in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The level of intracranial pressure in the observation group was lower than that in the control group at 1 d and 1 week after surgery,and the differences were statistically significant(P<0.05).At two weeks after surgery,the score of Glasgow coma scale(GCS)in two groups were higher than those before surgery,and the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was 6.12%,which was lower than 22.45%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Progressive decompression during large bone flap decompression in the treatment of severe craniocerebral injury can effectively reduce the levels of BNP,PAI-1 and t-PA,improve the level of intracranial pressure and consciousness,and reduce the occurrence of postoperative complications.
Large bone flap decompressionProgressive decompressionSevere craniocerebral injurySerum brain natriuretic peptideIntracranial pressure
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