Changes and Clinical Significance of NT-proBNP and CREA Levels in Patients with Chronic Renal Insufficiency
Objective:To explore the changes and clinical significance of N-terminal pro B-type natriuretic peptide(NT-proBNP)and creatinine(CREA)levels in patients with chronic renal insufficiency(CRI).Method:A total of 86 patients with CRI admitted to the Shenzhen University General Hospital from July 2018 to June 2023 were selected as the observation group,and 100 healthy subjects who underwent physical examination during the same period were selected as the control group.The levels of NT-proBNP,CREA and glomerular filtration rate(GFR)between the two groups were compared,and the levels of indicators in different disease periods of the observation group were compared.The correlation between NT-proBNP,CREA and GFR was analyzed.Receiver operating characteristic(ROC)curve was used to analyze the value of NT-proBNP and CREA in diagnosing CRI.Result:The levels of NT-proBNP and CREA in the observation group were higher than those in the control group,and the GFR was lower,the differences were statistically significant(P＜0.05).The levels of NT-proBNP and CREA in end-stage patients with renal failure were higher than those in patients with renal insufficiency decompensation stage and renal failure stage,and which in patients with renal failure stage were higher than those in patients with renal insufficiency decompensation stage,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that NT-proBNP and CREA levels were negatively correlated with GFR in patients with CRI(r=-0.334,-0.326,P＜0.05).ROC curve showed that the area under the curve of NT-proBNP and CREA for diagnosis of CRI was 0.786 and 0.735,respectively.Conclusion:The levels of NT-proBNP and CREA in CRI patients are relatively high,and are positively correlated with the severity of the condition.They were applied to the diagnosis of CRI conditions has high diagnostic value.
Chronic renal insufficiencyN-terminal pro B-type natriuretic peptideCreatinine
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