Effects of Ciwujia Naoling Mixture on Gastrointestinal Symptoms and Inflammatory Factors in Patients with Irritable Bowel Syndrome
Objective:To study the effects of Ciwujia Naoling Mixture on gastrointestinal symptoms and inflammatory factors in patients with irritable bowel syndrome(IBS).Method:A total of 150 patients with IBS admitted to Heilongjiang Academy of Traditional Chinese Medicine Sciences from February 2021 to February 2023 were selected as the study objects.They were divided into study group and reference group according to computer numbering random method,with 75 cases in each group.The reference group was treated with Pinaverium Bromide,and the study group was treated with Ciwujia Naoling Mixture on the basis of the reference group.The score of gastrointestinal symptoms,the level of serum inflammatory factors,the content of intestinal flora and the level of brain intestinal peptide indexes were compared between the two groups.Result:After 4 weeks of treatment,the scores of gastrointestinal symptoms in both groups were lower than those before treatment,and the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).After 4 weeks of treatment,the levels of serum inflammatory factors in both groups were lower than those before treatment,and those in the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).After 4 weeks of treatment,the contents of Lactobacillus and Bifidobacterium in two groups were higher than those before treatment,and the contents of Enterobacterium were lower than those before treatment,and the contents of Lactobacillus and Bifidobacterium in study group were higher than those in reference group,and the contents of Enterobacterium were lower than those in reference group,the differences were statistically significant(P<0.05).After 4 weeks of treatment,the brain intestinal peptide indexes in both groups were lower than those before treatment,and those in the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).Conclusion:Ciwujia Naoling Mixture can improve gastrointestinal symptoms and inflammatory factors in patients with IBS,and can promote the recovery of intestinal flora brain intestinal peptide.
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