Study on Correlation between Fibrinolytic System and Immune Inflammatory Response of Postoperative Patients with Cerebral Hemorrhage
Objective:To investigate the correlation between fibrinolytic system and immune inflammatory response of postoperative patients with cerebral hemorrhage.Method:A total of 240 postoperative patients with cerebral hemorrhage who treated in Cardiovascular and Cerebrovascular Hospital of General Hospital of Ningxia Medical University from September 2020 to December 2022 were selected as the study objects,they were divided into conscious group,sleepiness group,lethargy group,light coma group,medium coma group and deep coma group according to the degree of consciousness impairment at the first day after surgery,with 40 cases in each group.Then the lymphocyte immunity indexes(CD3+,CD4+,CD8+,CD4+/CD8+ and CD19+),fibrinolytic indexes[fibrinogen(FIB),fibrinogen degradation products(FDP)and D-dimer(D-D)],inflammatory indexes(monocytes,neutrophils,lymphocytes,neutrophil/lymphocyte and platelet/monocyte)of six groups were detected and compared,and pearson correlation analysis was used to analyze the relationship between fibrinolytic indexes and lymphocyte immunity indexes and inflammatory indexes.Result:There were no significant differences in the lymphocyte immunity indexes,lymphocytes and platelet/monocyte between conscious group and sleepiness group(P>0.05);there were significant differences in other indexes among six groups(P<0.05);the CD3+,CD4+,CD4+/CD8+,CD19+ and lymphocytes of deep coma group were lowest,and the CD8+,fibrinolytic indexes and other inflammatory indexes were highest,the next were medium coma group,light coma group,lethargy group and sleepiness group.Pearson correlation analysis showed the fibrinolytic indexes were negatively correlated with lymphocytes,CD3+,CD4+,CD4+/CD8+,CD19+(P<0.05),and were positively correlated with CD8+,monocytes,neutrophils,neutrophil/lymphocyte and platelet/monocyte(P<0.05).Conclusion:The differences of fibrinolytic system and immune inflammatory response of postoperative patients with cerebral hemorrhage of different degree of consciousness impairment are significant,and they have close relationship,so their detection value in the surgical patients with cerebral hemorrhage are higher.
万方数据
维普
